Pharmacogenetics of inhaled corticosteroids and exacerbation risk in adults with asthma.
Ahmed EdrisEmmely W de RoosMichael J McGeachieKatia M C VerhammeGuy G BrusselleKelan G TantisiraCarlos IribarrenMeng LuAnn Chen WuBruno H StrickerLies LahoussePublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2021)
rs242941 in CRHR1 was associated with poor ICS response. Conversely, TBXT variants were associated with improved ICS response. These associations may reveal specific endotypes, potentially allowing prediction of exacerbation risk and ICS response.