Acute versus chronic methotrexate poisoning; a cross-sectional study.
Arman AhmadzadehNasim ZamaniHossein Hassanian-MoghaddamSeyed Kaveh HadeiyParinaz ParhizgarPublished in: BMC pharmacology & toxicology (2019)
Chronic MTX poisoning is more serious than acute toxicity and accompanies higher dermatologic, hematologic, and hepatic complications necessitating more aggressive treatments including administration of higher doses of leucovorin or bone marrow stimulants such as G-CSF. This may be attributable to the underlying diseases and features (including older ages) which predispose these patients to complications.
Keyphrases
- liver failure
- bone marrow
- drug induced
- end stage renal disease
- respiratory failure
- risk factors
- ejection fraction
- newly diagnosed
- physical activity
- chronic kidney disease
- mesenchymal stem cells
- oxidative stress
- aortic dissection
- prognostic factors
- intensive care unit
- hepatitis b virus
- community dwelling
- middle aged
- patient reported