Salivary Gland Mucosa-Associated Lymphoid Tissue-Type Lymphoma From Sjögren's Syndrome Patients in the Majority Express Rheumatoid Factors Affinity-Selected for IgG.
Richard J BendeJerry JanssenAnna BeentjesThera A M WormhoudtKoen WagnerErlin A HaackeFrans G M KroeseJeroen E J GuikemaCarel J M van NoeselPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
A majority of patients with SS-associated salivary gland MALT lymphoma express somatically mutated BCRs that are selected for monoreactive, high-affinity binding of IgG-Fc. These data underscore the notion that soluble IgG, most likely in immune complexes in inflamed tissues, is the principal autoantigen in the pathogenesis of a variety of B cell lymphomas, particularly SS-associated MALT lymphomas.