Deaf and hearing readers have different access to spoken phonology which may affect the representation and recognition of written words. We used ERPs to investigate how a matched sample of deaf and hearing adults (total n = 90) responded to lexical characteristics of 480 English words in a go/no-go lexical decision task. Results from mixed effect regression models showed a) visual complexity produced small effects in opposing directions for deaf and hearing readers, b) similar frequency effects, but shifted earlier for deaf readers, c) more pronounced effects of orthographic neighborhood density for hearing readers, and d) more pronounced effects of concreteness for deaf readers. We suggest hearing readers have visual word representations that are more integrated with phonological representations, leading to larger lexically-mediated effects of neighborhood density. Conversely, deaf readers weight other sources of information more heavily, leading to larger semantically-mediated effects and altered responses to low-level visual variables.