A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi.

Xiu-Rong WuYi ShenShu-Jun CuiXiao-Lei LuoChao-Jiang Xiao Bei Jiang

Published in: Natural products and bioprospecting (2020)

One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2-5) were isolated from the peeled roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data analyses. In addition, compound 1 exhibited moderate antimalarial activity against Plasmodium yoelii BY265RFP with the inhibition ratio of 17.8 ± 13.3% at the dose of 30 mg/kg/day.

Keyphrases

plasmodium falciparum
molecular docking
electronic health record
high intensity
high resolution
big data
data analysis
mass spectrometry