Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain.
Daniel FelskyEllis PatrickJulie A SchneiderSara MostafaviChris GaiteriNikolaos PatsopoulosDavid A BennettPhilip L De JagerPublished in: Molecular neurodegeneration (2018)
Our results demonstrate that global risk of inflammatory disease does not strongly influence aging-related cognitive decline but that susceptibility variants that influence peripheral immune function also alter microglial density and immune gene expression in the aging brain, opening a new perspective on the control of microglial and immune responses within the central nervous system. Further study on the molecular mechanisms of peripheral immune disease risk influencing glial cell activation will be required to identify key regulators of these pathways.
Keyphrases
- cognitive decline
- gene expression
- neuropathic pain
- immune response
- mild cognitive impairment
- oxidative stress
- resting state
- white matter
- dna methylation
- copy number
- single cell
- transcription factor
- functional connectivity
- stem cells
- spinal cord injury
- multiple sclerosis
- cerebrospinal fluid
- blood brain barrier
- brain injury
- subarachnoid hemorrhage