Glutathione peroxidase mimics based on conformationally-restricted, peri-like, 4,5-disubstituted fluorene dichalcogenides.

Kesar Jagdev Damiano Tanini Jack W Lownes Carlotta Figliola Louise Male Antonella Capperucci Richard S Grainger

Published in: Organic & biomolecular chemistry (2021)

Glutathione peroxidase (GPx) regulates cellular peroxide levels through glutathione oxidation. GPx-mimics based on 4,5-disubstituted fluorene diselenides, their oxides, and ditellurides show catalytic activities consistent with conformational restriction about the dichalcogen bond.

Keyphrases

hydrogen peroxide
molecular dynamics
molecular dynamics simulations
nitric oxide