Mitochondrial transplantation protects against sepsis-induced myocardial dysfunction by modulating mitochondrial biogenesis and fission/fusion and inflammatory response.
Behnaz MokhtariMasoud HamidiReza BadalzadehAta MahmoodpoorPublished in: Molecular biology reports (2022)
Mitotherapy improved mitochondrial function, biogenesis, and dynamic associated with SIRT-1/PGC-1α network and suppressed inflammatory response in CLP-induced sepsis model, therefore, offers a promising strategy to overcome life-threatening sepsis challenge.
Keyphrases
- inflammatory response
- oxidative stress
- diabetic rats
- acute kidney injury
- septic shock
- intensive care unit
- high glucose
- lipopolysaccharide induced
- lps induced
- toll like receptor
- drug induced
- skeletal muscle
- left ventricular
- signaling pathway
- heart failure
- ischemia reperfusion injury
- mesenchymal stem cells
- stem cells
- immune response
- bone marrow
- network analysis