Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) and liver fibrosis: A review.

Published in: Cell biochemistry and function (2018)

KCs and HSCs are two key cells for production of NOX in liver in relation to the pathology of liver fibrosis. NOX subtypes 1, 2, and 4 are inducers of fibrogenesis in liver. NOX activation favors hepatocyte apoptosis, HSC activation, and KC-mediated inflammatory cascade in liver, all of which are responsible for generation of liver fibrosis.

Keyphrases

liver fibrosis
cell cycle arrest
reactive oxygen species
oxidative stress
induced apoptosis
cell death
endoplasmic reticulum stress
signaling pathway
liver injury