Bioactive Arylnaphthalide Lignans from Justicia depauperata .

Billy Tchegnitegni TousssieRuland Tchuinkeu NguengangIsabelle Kamga MawaboRémy Bertrand TeponnoJean Jules Kezetas BankeuJean Rodolphe ChounaCeline Ngeufeu NkenfouLéon Azefack TapondjouNorbert SewaldBruno Ndjakou Lenta

Published in: Journal of natural products (2022)

Eleven previously undescribed arylnaphthalide lignans ( 1 - 11 ) together with seven known compounds were isolated from the whole plant of Justicia depauperata . The structures of 1 - 11 were elucidated by spectroscopic analysis and mass spectrometry. Compounds 6 (IC 50 = 4.1 μM) and 9 (IC 50 = 9.5 μM) displayed cytotoxic activity against the KB-3-1 cervical carcinoma cell line. This report provides an insight into the conformational equilibria occurring in the arylnaphthalide lignan constituents of this plant.

Keyphrases

mass spectrometry
high resolution
molecular docking
molecular dynamics simulations
liquid chromatography
molecular dynamics
single molecule
cell wall
capillary electrophoresis
high performance liquid chromatography
gas chromatography
tissue engineering