Isolation and characterisation of nasoseptal cartilage stem/progenitor cells and their role in the chondrogenic niche.

Zita M JessopAyesha Al-SabahIrina N SimoesStephanie E A BurnellIna Laura PieperCatherine A ThorntonIain S Whitaker

Published in: Stem cell research & therapy (2020)

Fibronectin-adherent CSPCs demonstrate a unique gene expression profile compared to non-fibronectin-adherent DNCs. DNCs cultured in isolation, without CSPCs, express fibroblastic phenotype with reduced chondrogenicity. Mixed populations of stem/progenitor cells and chondrocytes were required for optimal chondrogenesis, suggesting that CSPCs may be required to retain phenotypic stability and chondrogenic potential of DNCs. Crosstalk between DNCs and CSPCs is proposed based on SDF-1 signalling.

Keyphrases

mesenchymal stem cells
type iii
extracellular matrix
genome wide
endothelial cells
copy number
human health
gene expression
genome wide identification