Ca2+/calmodulin-dependent protein kinase II and protein kinase G oxidation contributes to impaired sarcomeric proteins in hypertrophy model.

Kamilla GömöriMelissa HerwigHeidi BuddeRoua HassounNusratul MostafiSaltanat ZhazykbayevaMarcel SiemeSuvasini ModiTamara SzabadosJudit PipisNikolett Farkas-MorvayIstván LepránGergely ÁgostonIstván BaczkóÁrpád KovácsAndreas MüggePéter FerdinandyAnikó GörbePéter BencsikNazha Hamdani

Published in: ESC heart failure (2022)

Our findings showed VO-induced cardiomyocyte dysfunction via deranged phosphorylation of myofilament proteins and signalling pathways due to increased oxidative state of CaMKII and PKG and this might contribute to the development of hypertrophy.

Keyphrases

protein kinase
high glucose
oxidative stress
diabetic rats
endothelial cells
hypertrophic cardiomyopathy
hydrogen peroxide
angiotensin ii
heart failure
atrial fibrillation
electron transfer