Elucidation of the genetic causes of bicuspid aortic valve disease.
Jan GehlenAnja StundlRadoslaw Marek DebiecFederica FontanaMarkus KraneDinara SharipovaChristopher P NelsonBaravan Al-KassouAnn Sophie GielJan Malte SinningChristopher Mh BruengerCarolin F ZelckLaura L KoebbePeter S BraundThomas R WebbSimon HetheringtonStephan EnsmingerBuntaro FujitaSalah A MohamedMalakh ShresthaHeike KruegerMatthias SiepeFabian Alexander KariPeter NordbeckLarissa BuravezkyMalte KelmVerena VeulemansMatti AdamStephan BaldusKarl-Ludwig LaugwitzYannick HaasMatthias KarckUwe MehlhornLars Oliver ConzelmannIngo BreitenbachCorinna LebherzPaul UrbanskiWon Keun KimJoscha KandelsDavid EllinghausUlrike Nowak-GoettlPer HoffmannFelix WirthStefanie DopplerHarald LahmMartina DreßenMoritz von ScheidtKatharina KnollThorsten KesslerChristian HengstenbergHeribert SchunkertGeorg NickenigMarkus M NöthenAidan P BolgerSalim Abdelilah-SeyfriedNilesh J SamaniJeanette ErdmannTeresa TrenkwalderJohannes SchumacherPublished in: Cardiovascular research (2022)
Our study provides a deeper understanding of the genetic risk architecture of BAV formation on the single-marker and polygenic level.