Integrated systems-genetic analyses reveal a network target for delaying glioma progression.

Liisi LaanistePrashant K SrivastavaJulianna StylianouNelofer SyedSilvia Cases-CunilleraKirill ShkuraQingyu ZengOwen J L RackhamSarah R LangleyAndrée Delahaye-DuriezKevin O'NeillMatthew WilliamsAlbert BeckerFederico Roncaroli Enrico Petretto Michael R Johnson

Published in: Annals of clinical and translational neurology (2019)

Our results identify M2 as a multitarget network characteristic for astrocytoma progression and encourage M2-based drug screening to identify new compounds for preventing glioma transformation.

Keyphrases

genome wide
single cell
copy number
dna methylation
gene expression
network analysis