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Integrated systems-genetic analyses reveal a network target for delaying glioma progression.

Liisi LaanistePrashant K SrivastavaJulianna StylianouNelofer SyedSilvia Cases-CunilleraKirill ShkuraQingyu ZengOwen J L RackhamSarah R LangleyAndrée Delahaye-DuriezKevin O'NeillMatthew WilliamsAlbert BeckerFederico RoncaroliEnrico PetrettoMichael R Johnson
Published in: Annals of clinical and translational neurology (2019)
Our results identify M2 as a multitarget network characteristic for astrocytoma progression and encourage M2-based drug screening to identify new compounds for preventing glioma transformation.
Keyphrases
  • genome wide
  • single cell
  • copy number
  • dna methylation
  • gene expression
  • network analysis