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Influence of common dietary supplements (curcumin, andrographolide, and d-limonene) on the radiobiological responses of p53-competent colonic cancer epithelial cells.

Dusan VukmirovicNguyen T K VoColin SeymourDave RolloCarmel Mothersill
Published in: International journal of radiation biology (2021)
Curcumin, andrographolide, and d-limonene are known to have many chemoprotective benefits. This work shows that they, however, did not protect colonic epithelial HCT116 p53+/+ cells from radiation killing. As HCT116 p53+/+ cells are tumourigenic in nature, this finding implies that these three dietary compounds would not reduce the killing efficacy of radiation in gastrointestinal tumorigenesis. The post-irradiation radiosensitizing effect of d-limonene was an intriguing observation worth further investigation.
Keyphrases
  • cell cycle arrest
  • cell death
  • pi k akt
  • induced apoptosis
  • papillary thyroid
  • radiation induced
  • ulcerative colitis
  • endoplasmic reticulum stress
  • squamous cell carcinoma