Sex-specific regulation of cardiac microRNAs targeting mitochondrial proteins in pressure overload.

Hugo Sanchez-RuderischAna Maria QueirósDaniela FliegnerClaudia EschenGeorgios KararigasVera Regitz-Zagrosek

Published in: Biology of sex differences (2019)

We put forward that the male-specific induction of miRNAs and corresponding downregulation of downstream protein targets involved in mitochondrial metabolism may contribute to sex-specific remodeling in PO-induced LVH.

Keyphrases

oxidative stress
diabetic rats
high glucose
cell proliferation
signaling pathway
cancer therapy
drug induced
protein protein
amino acid
heart failure
binding protein
endothelial cells
stress induced