Therapeutic Targeting of Stromal-Tumor HGF-MET Signaling in an Organotypic Triple-Negative Breast Tumor Model.
Sunil SinghAstha LamichhanePouria Rafsanjani NejadJacob HeissHannah BaumannRavindra GudneppanavarNic D LeipzigMichael C KonopkaGary D LukerHossein TavanaPublished in: Molecular cancer research : MCR (2022)
Leveraging a state-of-the-art organotypic tumor model, we demonstrated that CAFs-mediated HGF-MET signaling drive tumorigenic activities in TNBC and presents a therapeutic target.