Understanding the dynamics of TKI-induced changes in the tumor immune microenvironment for improved therapeutic effect.
Conghua LuZiyuan GaoDi WuJie ZhengChen HuDaijuan HuangChao HeYihui LiuCaiyu LinTao PengYuanyao DouYimin ZhangFenfen SunWeiling JiangGuoqing YinRui HanYong HePublished in: Journal for immunotherapy of cancer (2024)
These findings offer new insights into the dynamics of TKI-induced changes in the TME, improving our understanding of NSCLC challenges. The study underscores the critical role of the TME in TKI resistance and suggests that adjunct therapies, like aspirin, may provide new strategies to enhance TKI efficacy and overcome resistance.