Crumbs2 Is an Essential Slit Diaphragm Protein of the Renal Filtration Barrier.

Annika Möller-KeruttJuan E Rodriguez-GaticaKarin WackerRohan BhatiaJan-Peter SiebrasseNanda BoonVeerle Van MarckPeter BoorUlrich KubitscheckJan WijnholdsHermann PavenstädtThomas Weide

Published in: Journal of the American Society of Nephrology : JASN (2021)

Crb2 is an essential component of the podocyte's slit diaphragm, interacting with Nephrin. Loss of slit diaphragm targeting and increasing ER stress are pivotal factors for onset and progression of CRB2-related SRNS.

Keyphrases

mechanical ventilation
acute respiratory distress syndrome
intensive care unit
cancer therapy
protein protein
binding protein
amino acid
small molecule
protein kinase