Oral Pharmacokinetics in Beagle Dogs of the Mitragynine Metabolite, 7-Hydroxymitragynine.
Elizabeth A MaxwellTamara I KingShyam H KambleKanumuri Siva Rama RajuErin C BertholdFrancisco LeónAidan HampsonLance R McMahonChristopher R McCurdyAbhisheak SharmaPublished in: European journal of drug metabolism and pharmacokinetics (2021)
These results provide the first pharmacokinetic and safety data for 7-HMG in the dog and therefore contribute to the understanding of the putative pharmacologic role of 7-HMG resulting from an oral delivery of mitragynine from kratom.
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