Efficiently targeted therapy of glioblastoma xenograft via multifunctional biomimetic nanodrugs.
Zhipeng YaoXiaochun JiangHong YaoYafeng WuFan ZhangCheng WangChenxue QiChenhui ZhaoZeyu WuMin QiJia ZhangXiaoxiang CaoZhichun WangFei WuChengyun YaoSongqin LiuShizhang LingHongping XiaPublished in: Biomaterials research (2022)
We showed that CMS/PEG-DOX-M inhibited cell proliferation of U87 MG cells and effectively induced cell apoptosis of U87 MG cells. Intracranial antitumor experiments showed that free DOX hardly penetrated the BBB, but CMS/PEG-DOX-M effectively reached the orthotopic intracranial tumor through the BBB and significantly inhibited tumor growth. Immunofluorescence staining of orthotopic tumor tissue sections confirmed that nanodrugs promoted apoptosis of tumor cells. This study developed a multimodal nanodrug treatment system with the enhanced abilities of tumor-targeting, BBB penetration, and cancer-specific accumulation of chemotherapeutic drugs by combining chemotherapy and photothermal therapy. It can be used as a flexible and effective GBM treatment system and it may also be used for the treatment of other central nervous systems (CNS) tumors and extracranial tumors.
Keyphrases
- cell proliferation
- cell cycle arrest
- drug delivery
- oxidative stress
- squamous cell carcinoma
- cell cycle
- radiation therapy
- combination therapy
- locally advanced
- endoplasmic reticulum stress
- internal carotid artery
- signaling pathway
- high glucose
- endothelial cells
- metal organic framework
- middle cerebral artery
- smoking cessation
- childhood cancer