Pigment Epithelium-Derived Factor-Loaded PEGylated Nanoparticles as a New Antiangiogenic Therapy for Neovascularization.

Feng Zhao Wenlei Fei Zhouyue Li Hanyang Yu Lei Xi

Published in: Journal of diabetes research (2022)

Our study is the first to demonstrate that NP-PEG-PEDF exert antiangiogenic effects on high glucose-stimulated HUVECs and have the potential to alleviate microvascular dysfunction. These data suggest that the NP-PEG-PEDF delivery system may offer an innovative therapeutic strategy for preventing neovascularization of the fundus.

Keyphrases

high glucose
drug delivery
diabetic retinopathy
endothelial cells
vascular endothelial growth factor
electronic health record
oxidative stress
optical coherence tomography
risk assessment
climate change
wound healing
artificial intelligence