Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase.

Marie-Sophie Nguyen-TuJoseph HarrisAida Martinez-SanchezPauline ChabosseauMing HuEleni GeorgiadouAlice PollardPablo OteroLivia Lopez-NoriegaIsabelle LeclercKei SakamotoDieter SchmollDavid M SmithDavid CarlingGuy A Rutter

Published in: Diabetologia (2022)

AMPK activation exerts complex, time-dependent effects on insulin secretion. These observations should inform the design and future clinical use of AMPK modulators.

Keyphrases

protein kinase
liver failure
drug induced

small molecule
respiratory failure
current status

transcription factor
aortic dissection
skeletal muscle

intensive care unit
extracorporeal membrane oxygenation
mechanical ventilation