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Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping.

Quanyi ZhaoMichael DacreTrieu NguyenMilos PjanicBoxiang LiuDharini IyerPaul ChengRobert WirkaJuyong Brian KimHunter B FraserThomas Quertermous
Published in: Genome biology (2020)
Together, these studies represent the most thorough mapping of multiple QTL types in a highly disease-relevant primary cultured cell type and provide novel insights into their functional overlap and mechanisms that underlie these genomic features and their relationship to disease risk.
Keyphrases
  • genome wide
  • gene expression
  • coronary artery disease
  • dna damage
  • heart failure
  • single cell
  • dna methylation
  • left ventricular
  • binding protein
  • transcatheter aortic valve replacement
  • genome wide association