Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping.
Quanyi ZhaoMichael DacreTrieu NguyenMilos PjanicBoxiang LiuDharini IyerPaul ChengRobert WirkaJuyong Brian KimHunter B FraserThomas QuertermousPublished in: Genome biology (2020)
Together, these studies represent the most thorough mapping of multiple QTL types in a highly disease-relevant primary cultured cell type and provide novel insights into their functional overlap and mechanisms that underlie these genomic features and their relationship to disease risk.