Subtle vascular and astrocytic changes in the brain of coronavirus disease 2019 (COVID-19) patients.

Gabriela Camelia RosuValentin Octavian MateescuAlexandra SimionescuAnca-Maria Istrate-OfiteruGeorge Cristian CurcăIonica PiriciLaurentiu MogoantaIon MindrilaSamir Kumar-SinghSorin HostiucDaniel-Nicolae Pirici

Published in: European journal of neurology (2022)

Our data on the irregularity of the basement membranes, loss of endothelial tight junction, reduction of the astrocyte end-feet and decrease of AQP4 suggest subtle morphological changes of the blood-brain barrier in COVID-19 brains that could be linked with indirect inflammatory signalling or hypoxia/hypercapnia.

Keyphrases

coronavirus disease
endothelial cells
sars cov
blood brain barrier
respiratory syndrome coronavirus
electronic health record
resting state
white matter
oxidative stress
big data
cerebral ischemia
functional connectivity
multiple sclerosis
machine learning
data analysis
artificial intelligence