Dopaminergic Depletion, β-Amyloid Burden, and Cognition in Lewy Body Disease.
Han Soo YooSangwon LeeSeok Jong ChungYang Hyun LeePhil Hyu LeeYoung H SohnSeungyeoun LeeMijin YunByoung Seok YePublished in: Annals of neurology (2020)
Our results suggest that occipital β-amyloid deposition may contribute to the association between striatal dopaminergic depletion and visuospatial dysfunction in LBD patients. Although the effects of reduced DAT activity are more prominent than those of β-amyloid burden on cognitive dysfunction, the latter affects the onset of cognitive dysfunction. ANN NEUROL 2020;87:739-750.