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Effect of age on metabolomic changes in a model of paclitaxel-induced peripheral neurotoxicity.

Roberta BonomoAnnalisa CantaAlessia ChiorazziValentina Alda CarozziCristina MeregalliEleonora PozziPaola AlbertiCecile F FrampasDaan R van der VeenPaola MarmiroliDebra Jean SkeneGuido Cavaletti
Published in: Journal of the peripheral nervous system : JPNS (2023)
Our study identifies for the first time multiple related metabolic axes involved in PTX-induced peripheral neurotoxicity, and suggests age-related differences in CIPN manifestations and in the metabolic profile. This article is protected by copyright. All rights reserved.
Keyphrases
  • chemotherapy induced
  • high glucose
  • diabetic rats
  • drug induced
  • genome wide
  • gene expression