Dose-Exposure-Response Analysis of the Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone on UACR and eGFR: An Analysis from FIDELIO-DKD.

Sebastiaan Camiel Goulooze Hiddo J Lambers Heerspink Martijn van NoortNelleke SnelderMeike Brinker Joerg Lippert Thomas Eissing

Published in: Clinical pharmacokinetics (2022)

We developed a model that accurately describes the finerenone dose-exposure-response relationship for UACR and eGFR. The model demonstrated that the early UACR effect of finerenone predicted its long-term effect on eGFR decline. These effects were independent of concomitant SGLT2i use.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
tyrosine kinase