Dose-Dependent Tranexamic Acid Blunting of Penumbral Leukocyte Mobilization and Blood-Brain Barrier Permeability Following Traumatic Brain Injury: An In Vivo Murine Study.

Matthew C CulkinPriyanka BeleAnastasia P GeorgesPatricia SantosGrace NiziolekLewis J KaplanDouglas H SmithJose L Pascual

Published in: Neurocritical care (2024)

Only higher TXA dosing definitively abrogates penumbral leukocyte mobilization, preserving BBB integrity post TBI. Some neuroclinical recovery is observed, even with lower TXA dosing. Better outcomes with higher dose TXA after TBI may occur secondary to blunting of leukocyte-mediated penumbral cerebrovascular inflammation.

Keyphrases

blood brain barrier
traumatic brain injury
peripheral blood
cerebral ischemia
severe traumatic brain injury
oxidative stress
endothelial cells
type diabetes
insulin resistance
metabolic syndrome
brain injury
adipose tissue
glycemic control
weight loss