Evaluation of urine concentrations of amoxicillin and clavulanate in cats.
Kate S KuKanichKallie WoodruffZackery BieberlyMark G PapichButch KuKanichPublished in: Journal of veterinary internal medicine (2020)
Orally administered amoxicillin-clavulanate resulted in urine amoxicillin concentrations above the cutoff (8 μg/mL) for wild-type Escherichia coli in all cats. Because urine-specific susceptibility testing breakpoints can be determined using urine concentrations, this information should allow new CLSI uropathogen susceptibility breakpoints for amoxicillin and amoxicillin-clavulanate in healthy cats, increasing the urine breakpoint from ≤0.25 to ≤8 μg/mL.