Aiming at the problem of low efficiency of capturing respirable and hydrophobic dust in water mist dust removal technology, a chemical dust suppression method is adopted. Based on the research idea of improving the wetting efficiency of water mist, prolonging the droplet retention time, and improving the contact opportunity with dust, the experiments of dust sedimentation time, solution spreading area, and water loss rate are selected to evaluate the wetting efficiency and anti-evaporation performance of dust suppression water mist. Considering the special double-chain structure of the Gemini surfactant and its high wettability, it is preferred as the main dust suppression component. Based on the indoor experimental data, the optimized formula of the composite wet water mist dust suppressant was obtained by CCD-RSM(central composite design-response surface methodology). The comparison of indoor experimental data shows that the sedimentation time of the dust sample in the water mist dust suppressant is 5.0 times faster than that of pure water, the spreading area of the dust suppressant solution is 1.8 times that of pure water, and the water loss rate of the dust sample treated by the dust suppressant is 70% that of pure water. The field investigation results show that compared with pure water mist, the dust removal rates of the Gemini wetting dust suppressant for respirable dust and total dust are 90.3 and 71.1%, respectively, which are 10.5 and 22.5% higher than that of pure water mist. It can be proved that improving the wetting efficiency and anti-evaporation performance of spray mist will increase the dust removal efficiency.