Prospective Evaluation of the Fungitell® (1→3) Beta-D-Glucan Assay as a Diagnostic Tool for Invasive Fungal Disease in Pediatric Allogeneic Hematopoietic Cell Transplantation: A Report from the Children's Oncology Group.

William R OttoChristopher C DvorakCraig L K BogeLuis Ostrosky-ZeichnerAdam J EsbenshadeMichael L NiederSarah AlexanderWilliam J SteinbachHa DangDoojduen VillalunaLu ChenMicah A SkeensTheoklis E ZaoutisLillian SungBrian T Fisher

Published in: Pediatric transplantation (2022)

Fungitell® BDG screening is of limited utility in diagnosing IFD in the post-HCT period, mainly due to high false-positive rates. Fungitell® BDG surveillance testing should not be performed in children during the early post-HCT period while receiving antifungal prophylaxis as the pretest probability for IFD is low.

Keyphrases

young adults
stem cell transplantation
public health
bone marrow
palliative care
high throughput
candida albicans
low dose
cell death
signaling pathway