Structural alterations and markers of endothelial activation in pulmonary and bronchial arteries in fatal asthma.
Renata Calciolari RossiRaquel AnonniDiogenes Seraphim FerreiraLuiz Fernando Ferraz da SilvaThais MauadPublished in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2019)
Our data suggest that the mechanisms linking asthma and arterial functional abnormalities might involve systemic rather than local mediators. Loss of collagen III in the PA was observed in smoking asthma patients, and this was compatible with the degradative environment induced by cigarette smoking. Our data also reinforce the idea that the mechanisms of leukocyte efflux via adhesion molecules differ between bronchial and pulmonary circulation, which might be relevant to understanding and treating the distal lung in asthma.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- allergic rhinitis
- end stage renal disease
- chronic kidney disease
- electronic health record
- newly diagnosed
- ejection fraction
- prognostic factors
- endothelial cells
- escherichia coli
- peritoneal dialysis
- biofilm formation
- pseudomonas aeruginosa
- data analysis
- staphylococcus aureus
- patient reported outcomes
- artificial intelligence