Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease.
Yufang BiYuemiao ZhangHumaira RasheedVenexia M WalkerYuka SugawaraJiachen LiYue LengBenjamin ElsworthRobyn E WoottonSi FangQian YangStephen BurgessPhilip C HaycockMaria Carolina BorgesYoonsu ChoRebecca CarnegieAmy HowellJamie RobinsonLaurent F ThomasBen Michael BrumptonKristian HveemStein HallanNora FranceschiniAndrew P MorrisAnna KöttgenCristian PattaroMatthias WuttkeMasayuki YamamotoNaoki KashiharaMasato AkiyamaMasahiro KanaiKoichi MatsudaYoichiro KamataniYukinori OkadaRobin WaltersIona Y MillwoodZhengming ChenGeorge Davey SmithSean BarbourCanqing YuBjørn Olav ÅsvoldHong ZhangTom R GauntPublished in: International journal of epidemiology (2021)
Eight cardiometabolic risk factors showed causal effects on CKD in Europeans and three of them showed causality in East Asians, providing insights into the design of future interventions to reduce the burden of CKD.