Tongxinluo Activates PI3K/AKT Signaling Pathway to Inhibit Endothelial Mesenchymal Transition and Attenuate Myocardial Fibrosis after Ischemia-Reperfusion in Mice.
Ya-Ru WeiYun-Long HouYu-Jie YinZhen LiYi LiuNing-Xin HanZi-Xuan WangLu LiuXiao-Qi WangYuan-Jie HaoKun MaJiao-Jiao GuZhen-Hua JiaPublished in: Chinese journal of integrative medicine (2024)
TXL activated the PI3K/AKT signaling pathway to inhibit EndMT and attenuated myocardial fibrosis after MIRI in mice.
Keyphrases
- pi k akt
- signaling pathway
- cell cycle arrest
- cell proliferation
- high fat diet induced
- left ventricular
- induced apoptosis
- epithelial mesenchymal transition
- bone marrow
- stem cells
- endothelial cells
- heart failure
- type diabetes
- insulin resistance
- oxidative stress
- liver fibrosis
- cell death
- skeletal muscle
- atrial fibrillation