Effects of gene-lifestyle interactions on obesity based on a multi-locus risk score: A cross-sectional analysis.
Sho NakamuraXuemin FangYoshinobu SaitoHiroto NarimatsuAzusa OtaHiroaki IkezakiChisato ShimanoeKeitaro TanakaYoko KuboMineko TsukamotoTakashi TamuraAsahi HishidaIsao OzeYuriko N KoyanagiYohko NakamuraMiho KusakabeToshiro TakezakiDaisaku NishimotoSadao SuzukiTakahiro OtaniNagato KuriyamaDaisuke MatsuiKiyonori KurikiAya KadotaYasuyuki NakamuraKokichi ArisawaSakurako Katsuura-KamanoMasahiro NakatochiYukihide MomozawaMichiaki KuboKenji TakeuchiKenji WakaiPublished in: PloS one (2023)
Our results provide evidence of an interaction effect between GRS and nutritional intake and physical activity. This gene-lifestyle interaction provides a basis for developing prevention or treatment interventions for obesity according to individual genetic predisposition.
Keyphrases
- physical activity
- metabolic syndrome
- weight loss
- genome wide
- copy number
- insulin resistance
- weight gain
- high fat diet induced
- type diabetes
- body mass index
- genome wide identification
- skeletal muscle
- sleep quality
- transcription factor
- combination therapy
- depressive symptoms
- genome wide association study
- genome wide analysis
- smoking cessation
- replacement therapy