Stereospecific recognition of a chiral centre over multiple flexible covalent bonds by 19 F-NMR.

High performance in chiral recognition by a reactive 19 F-tag was demonstrated for a variety of enantiomers. The analytes with up to five flexible covalent bonds from the chiral center can be discriminated by a sensitive chiral reporter manifested in the 19 F-NMR spectrum. Simultaneous identification of chiral amines in a mixture and high accuracy ee determination were achieved.