Single molecule array measures of LRRK2 kinase activity in serum link Parkinson's disease severity to peripheral inflammation.

Yuan YuanHuizhong LiKashyap SreeramTuyana MalankhanovaRavindra BodduSamuel StraderAllison ChangNicole BryantTalene A YacoubianDavid G StandaertMadalynn ErbDarren J MooreLaurie H SandersMichael W LutzDmitry VelmeshevAndrew B West

Published in: Molecular neurodegeneration (2024)

The extracellular serum ratio of pT73-Rab10 to total Rab10 is a novel pharmacodynamic biomarker for LRRK2-linked innate immune activation associated with disease severity in iPD. We propose that those iPD patients with higher serum pT73-Rab10 levels may benefit from LRRK2-targeting therapeutics that mitigate associated deleterious immunological responses.

Keyphrases

single molecule
innate immune
oxidative stress
small molecule
high throughput
high resolution
living cells
cancer therapy
mass spectrometry
high speed