Mfd protects against oxidative stress in Bacillus subtilis independently of its canonical function in DNA repair.
Holly Anne MartinKatelyn E PorterCarmen VallinTatiana ErmiNatalie ContrerasMario Pedraza-ReyesEduardo A RobletoPublished in: BMC microbiology (2019)
These results are significant because they show that Mfd mediates error-prone repair of DNA and protects cells against oxidation of proteins by affecting gene expression; Mfd deficiency resulted in increased gene expression of the OhrR repressor which controls the cellular response to organic peroxide exposure. These observations point to Mfd functioning beyond a DNA repair factor in cells experiencing oxidative stress.
Keyphrases
- dna repair
- dna damage
- induced apoptosis
- gene expression
- oxidative stress
- bacillus subtilis
- endoplasmic reticulum stress
- dna damage response
- cell cycle arrest
- dna methylation
- signaling pathway
- ischemia reperfusion injury
- circulating tumor
- hydrogen peroxide
- diabetic rats
- cell free
- smoking cessation
- circulating tumor cells