Global Meta-Analysis of Organoid And Organ-on-Chip Research.

Organoids and cells in organ-on-chip platforms replicate higher-level anatomical, physiological or pathological states of tissues and organs. These technologies are widely regarded by academia, the pharmacological industry and regulators as key biomedical developments. To map advances in this emerging field, we performed a meta-analysis based on a quality-controlled text-mining algorithm. The analysis covers titles, keywords and abstracts of categorized academic publications in the literature and preprint databases published after 2010. The algorithm identified and tracked 149 and 107 organs or organ substructures modelled as organoids and organ-on-chip, respectively, stem cell sources, as well as 130 diseases, and 16 groups of organisms other than human and mouse in which organoid/organ-on-chip technology has been applied. The meta-analysis illustrates changing diversity and focus in organoid/organ-on-chip research and captures its geographical distribution. The downloadable dataset we provide is a robust framework for researchers to interrogate with their own questions. This article is protected by copyright. All rights reserved.