Central nervous system evaluation of an ethanol extract of Bidens odorata Cav (Asteraceae) leaves, and its antinociceptive interaction with paracetamol and naproxen.
Ángel Josabad Alonso-CastroJuan Ramón Zapata-MoralesCesar Solorio-AlvaradoAndrea Hernández-SantiagoLuis Antonio Espinoza-RamírezCandy Carranza-ÁlvarezVelayudham RamadossPublished in: Inflammopharmacology (2019)
BOE induces sedative and anticonvulsant effects. The anxiolytic actions shown by BOE are probably induced by the participation of the GABAergic system. BOE exerts antinociceptive synergistic interaction with paracetamol and naproxen probably by the participation of nitric oxide and ATP-sensitive K+ channels, respectively.