Targeting specificity protein 1 with miR-128-3p overcomes TGF-β1 mediated epithelial-mesenchymal transition in breast cancer: An in vitro study.

Lakshmi Vineela NallaPiyush GondaliyaKiran KaliaLakshmi Vineela Nalla

Published in: Molecular biology reports (2022)

Upregulated miR-128-3p inhibited SP1, thereby limiting the TGF-β1 induced EMT in MCF-7 and MDA-MB-231 cell lines for the first time. This study may pave the path to explore novel miRNA therapeutics for eradicating advanced breast cancer cases.

Keyphrases

epithelial mesenchymal transition
transforming growth factor
breast cancer cells

signaling pathway
diabetic rats
small molecule

amino acid
drug delivery

breast cancer risk
endothelial cells