Association between lipoprotein(a), LPA genetic risk score, aortic valve disease, and subsequent major adverse cardiovascular events.
Matthew K MooreGregory T JonesSally P A McCormickMichael J A WilliamsSean CoffeyPublished in: European journal of preventive cardiology (2024)
An LPA GRS can explain 45% of variation in Lp(a) levels, and both Lp(a) and the GRS are associated with CAVD. An elevated GRS is associated with future cardiac events in a secondary risk setting, but, if the CAD status is known, it does not provide additional prognostic information.
Keyphrases
- aortic valve
- cardiovascular events
- coronary artery disease
- transcatheter aortic valve replacement
- aortic stenosis
- transcatheter aortic valve implantation
- aortic valve replacement
- cardiovascular disease
- genome wide
- current status
- health information
- copy number
- emergency department
- dna methylation
- atrial fibrillation
- low density lipoprotein