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A Visible-Light-Driven Iminyl Radical-Mediated C-C Single Bond Cleavage/Radical Addition Cascade of Oxime Esters.

Xiao-Ye YuJia-Rong ChenPeng-Zi WangMeng-Nan YangDong LiangWen-Jing Xiao
Published in: Angewandte Chemie (International ed. in English) (2017)
A room-temperature, visible-light-driven N-centered iminyl radical-mediated and redox-neutral C-C single bond cleavage/radical addition cascade reaction of oxime esters and unsaturated systems has been accomplished. The strategy tolerates a wide range of O-acyl oximes and unsaturated systems, such as alkenes, silyl enol ethers, alkynes, and isonitrile, enabling highly selective formation of various chemical bonds. This method thus provides an efficient approach to various diversely substituted cyano-containing alkenes, ketones, carbocycles, and heterocycles.
Keyphrases
  • visible light
  • room temperature
  • ionic liquid
  • electron transfer
  • molecular docking
  • transcription factor