FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX.

Linlin JiQingzhu WangFengjuan HuangTingting AnFeng GuoYanyan ZhaoYang LiuYanyan HeYi SongGuijun Qin

Published in: Oxidative medicine and cellular longevity (2019)

The regulatory role of FOXO1/TXNIP-TRX activation in DN can protect against the high glucose-induced renal proximal tubular cell injury by attenuating cellular ROS production. Modulating the FOXO1/TXNIP-TRX pathway may be a new therapeutic target in DN.

Keyphrases

high glucose
transcription factor
nlrp inflammasome
endothelial cells
signaling pathway
pi k akt
cell cycle arrest
cell death
type diabetes
oxidative stress
single cell
cell proliferation
endoplasmic reticulum stress
cell therapy
dna damage