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Cardiac remodeling after anthracycline and radiotherapy exposure in adult survivors of childhood cancer: A report from the St Jude Lifetime Cohort Study.

John Lynn JefferiesWojciech M MazurCarrie R HowellJuan C PlanaKristen K NessZhenghong LiVijaya M JoshiDaniel M GreenDaniel A MulrooneyJeffrey A TowbinHugo R MartinezJudith D GoldbergRebecca M HowellDeo Kumar SrivastavaLeslie L RobisonMelissa M HudsonGregory T Armstrong
Published in: Cancer (2021)
Chest radiation therapy, but not anthracycline therapy, increased the risk for concentric remodeling in survivors of childhood cancer. The presence of concentric remodeling was associated with increased exercise intolerance.
Keyphrases
  • childhood cancer
  • young adults
  • radiation therapy
  • early stage
  • locally advanced
  • left ventricular
  • physical activity
  • squamous cell carcinoma
  • heart failure
  • stem cells
  • mesenchymal stem cells
  • body composition