Magnetic relaxation switching assay based on three-dimensional assembly of Fe 3 O 4 @ZIF-8 for detection of cadmium ions.

The design and construction of a novel magnetic resonance switch (MRS) sensor for cadmium ion (Cd 2+ ) detection is described. Fe 3 O 4 @ZIF-8 was synthesized through seed-mediated growth of dimercaptosuccinic acid-coated Fe 3 O 4 . Fe 3 O 4 @ZIF-8 with high relaxation value (163.086 mM -1 s -1 ) and large negative zeta potential (-20.69 mV) exhibited good magnetic relaxation performance and water solubility. The successfully synthesized Fe 3 O 4 @ZIF-8 was used to develop an immune recognition-based MOFs-MRS sensor for highly sensitive detection of Cd 2+ . The proposed MRS detected a wide linear range of Cd 2+ concentration from 2 to 200 ng mL -1 with a low limit of detection of 0.65 ng mL -1 ( S / N = 3), and displayed high selectivity towards matrix interference. The robust sensing system was effective even in a complex sample matrix, enabling the quantitative analysis of Cd 2+ content in rice samples and drinking water samples with good reliability. Recoveries of Cd 2+ ranged from 91.50 to 112.05% for spiked drinking water and from 95.86 to 110.45% for spiked rice samples. The versatility of Fe 3 O 4 @ZIF-8 with customized relaxation responses could allow the adaptation of magnetic resonance platforms for food safety purposes.