Antigen-driven selection of antibodies against SSA, SSB and the centromere 'complex', including a novel antigen, MIS12 complex, in human salivary glands.

Masaru TakeshitaKatsuya SuzukiYukari KanedaHumitsugu YamaneKazuhiro IkeuraHidekazu SatoShin KatoKazuyuki TsunodaHisashi AraseTsutomu Takeuchi

Published in: Annals of the rheumatic diseases (2019)

We showed direct evidences of antigen-driven maturation of anti-SSA/SSB antibody and ACA in SS lesion. ACA recognises centromere 'complex' rather than individual protein, and this feature is common among patients with SS, SSc and PBC.

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