Type I Interferon Receptor Subunit 1 Deletion Attenuates Experimental Abdominal Aortic Aneurysm Formation.

Takahiro Shoji Jia Guo Yingbin GeYankui LiGang LiToru IkezoeWei WangXiaoya ZhengSihai Zhao Naoki FujimuraJianhua HuangBaohui XuRonald L Dalman

Published in: Biomolecules (2022)

IFNAR1 deficiency limited experimental AAA progression in response to intra-aortic elastase infusion. Combined with clinical observations, these results suggest an important role for IFNAR1 activity in AAA pathogenesis.

Keyphrases

abdominal aortic aneurysm
aortic valve
dendritic cells
low dose
left ventricular
heart failure
immune response
replacement therapy
protein kinase
binding protein
aortic dissection
pulmonary arterial hypertension
smoking cessation