Real-world application of the pediatric Glucocorticoid Toxicity Index in childhood-onset lupus.
Emily ZhangSarah CapponiRebecca ScobellGabrielle AlonziMadeline HlobikAnkana DagaEsra MeidanHolly WobmaLiyoung KimLauren A HendersonSiobhan CasePeter A NigrovicJohn H StoneKaren H CostenbaderMary Beth F SonJoyce C ChangPublished in: Seminars in arthritis and rheumatism (2024)
Patients with pSLE experience a high burden of GC toxicity, particularly related to blood pressure, BMI, sleep, and growth. Standardized, pediatric-specific GC toxicity assessment is feasible in real-world settings and can facilitate evaluation of strategies to reduce morbidity in children requiring chronic GC treatment.
Keyphrases
- blood pressure
- oxidative stress
- gas chromatography
- systemic lupus erythematosus
- young adults
- body mass index
- childhood cancer
- oxide nanoparticles
- type diabetes
- heart rate
- disease activity
- rheumatoid arthritis
- risk factors
- depressive symptoms
- adipose tissue
- weight gain
- hypertensive patients
- mass spectrometry
- sleep quality
- blood glucose
- insulin resistance
- smoking cessation